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- Title
5' flanking variants of resistin are associated with obesity.
- Authors
Engert, James C.; Vohl, Marie-Claude; Williams, Scott M.; Lepage, Pierre; Loredo-Osti, J C.; Faith, Janet; Doré, Carole; Renaud, Yannick; Burtt, Noë P.; Villeneuve, Amélie; Hirschhorn, Joel N.; Altshuler, David; Groop, Leif C.; Després, Jean-Pierre; Gaudet, Daniel; Hudson, Thomas J.; Doré, Carole; Burtt, Noël P; Villeneuve, Amélie; Després, Jean-Pierre
- Abstract
Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into the association of these SNPs with diabetes and obesity revealed two 5' flanking variants (g.-537 and g.-420), in strong linkage disequilibrium, that are associated with BMI. In nondiabetic individuals from the Quebec City area and the Saguenay-Lac-St-Jean region of Quebec, the g.-537 mutation (allelic frequency = 0.04) was significantly associated with an increase in BMI (P = 0.03 and P = 0.01, respectively). When the data from these two populations were combined and adjusted for age and sex, both the g.-537 (odds ratio [OR] 2.72, 95% CI 1.28-5.81) and the g.-420 variants (1.58, 1.06-2.35) were associated with an increased risk for a BMI > or =30 kg/m(2). In contrast, in case/control and family-based study populations from Scandinavia, we saw no effect on BMI with either of these promoter variants. No association was seen with diabetes in any of the population samples.
- Subjects
QUEBEC (Province); CANADA; GENETIC polymorphisms; DIABETES; OBESITY
- Publication
Diabetes, 2002, Vol 51, Issue 5, p1629
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.51.5.1629