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- Title
The IR[sub 1152] Mutant Insulin Receptor Selectively Impairs Insulin Action in Skeletal Muscle but Not in Liver.
- Authors
Caruso, Matilde; Miele, Claudia; Oliva, Andrea; Condorelli, Gerolama; Oriente, Francesco; Riccardi, Gabriele; Capaldo, Brunella; Fiory, Francesca; Accili, Domenico; Formisano, Pietro; Beguinot, Francesco
- Abstract
Determines the effect of IR1152 mutant insulin receptor on insulin action in liver and skeletal muscles of mice. Patterns of IRS-1 and IRS-2 phosphorylations in hepatocytes and skeletal muscles; Suppression of hepatic insulin production by insulin in patients with IR1152; Role of IR1152 in controlling glucose metabolism in the liver.
- Subjects
IR genes; INSULIN receptors; LIVER; ANIMAL experimentation
- Publication
Diabetes, 2000, Vol 49, Issue 7, p1194
- ISSN
0012-1797
- Publication type
Article
- DOI
10.2337/diabetes.49.7.1194