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- Title
Decreased blood-brain barrier permeability to sodium in early experimental diabetes.
- Authors
Knudsen, G. M.; Jakobsen, J.; Juhler, M.; Paulson, O. B.
- Abstract
Blood-brain barrier (BBB) permeability to 24Na+, 36Cl-, and [3H]sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeability-surface area product) for Na+ in the cortex of the frontal lobes was 5.4 +/- 0.6 (10(-5) cm3 X g-1 X s-1; +/- SD) in diabetic rats compared with 7.1 +/- 1.7 in control rats. In the occipital cortex, the values were 7.6 +/- 1.5 and 9.9 +/- 1.6, respectively. In contrast, BBB permeability to Cl- and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.
- Publication
Diabetes, 1986, Vol 35, Issue 12, p1371
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diab.35.12.1371