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- Title
Inhibition of microglial activation contributes to propofol-induced protection against post-cardiac arrest brain injury in rats.
- Authors
Wang, Wei; Lu, Rui; Feng, Da‐yun; Liang, Li‐rong; Liu, Bing; Zhang, Hui
- Abstract
It has been suggested that propofol can modulate microglial activity and hence may have potential roles against neuroinflammation following brain ischemic insult. However, whether and how propofol can inhibit post-cardiac arrest brain injury via inhibition of microglia activation remains unclear. A rat model of asphyxia cardiac arrest ( CA) was created followed by cardiopulmonary resuscitation. CA induced marked microglial activation in the hippocampal CA1 region, revealed by increased OX42 and P2 class of purinoceptor 7 (P2X7R) expression, as well as p38 MAPK phosphorylation. Morris water maze showed that learning and memory deficits following CA could be inhibited or alleviated by pre-treatment with the microglial inhibitor minocycline or propofol. Microglial activation was significantly suppressed likely via the P2X7R/p-p38 pathway by propofol. Moreover, hippocampal neuronal injuries after CA were remarkably attenuated by propofol. In vitro experiment showed that propofol pre-treatment inhibited ATP-induced microglial activation and release of tumor necrosis factor-α and interleukin-1β. In addition, propofol protected neurons from injury when co-culturing with ATP-treated microglia. Our data suggest that propofol pre-treatment inhibits CA-induced microglial activation and neuronal injury in the hippocampus and ultimately improves cognitive function.
- Subjects
CARDIAC arrest; CARDIOPULMONARY resuscitation; BRAIN injuries; HIPPOCAMPUS (Brain); PROPOFOL
- Publication
Journal of Neurochemistry, 2015, Vol 134, Issue 5, p892
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/jnc.13179