We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Primary Spindle Cell Sarcoma of the Lung with MGA::NUTM1 Fusion: An Extremely Rare Case of a Potentially Emerging Entity and Review of the Literature.
- Authors
Georgantzoglou, Natalia; Aghighi, Maryam; Cote, Gregory; Hung, Yin P.; Kerr, Darcy A.; Pettus, Jason; Linos, Konstantinos
- Abstract
Originally described in a rare subset of poorly differentiated squamous cell carcinomas termed NUT carcinomas, NUTM1 rearrangements are now known to characterize a wide spectrum of neoplasms including sarcomas, poromas/porocarcinomas, unclassified adnexal carcinomas and pediatric acute lymphoblastic leukemia. The advent of next-generation sequencing (NGS) has led to the identification of a multitude of novel fusion partners in addition to BRD4, which was initially reported in the majority of NUT carcinomas. NUTM1 -rearranged sarcomas usually harbor fusions with the MAD gene family (MXD1, MXD4, MGA) and present as spindle cell proliferations in diverse locations in patients of all ages. Herein, we present a very rare case of spindle cell sarcoma of the lung, which harbored a NUTM1::MGA fusion and offer a comprehensive update of the recent data.
- Subjects
LUNGS; SARCOMA; SQUAMOUS cell carcinoma; LITERATURE reviews; LYMPHOBLASTIC leukemia; GENE fusion
- Publication
International Journal of Surgical Pathology, 2022, Vol 30, Issue 8, p931
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/10668969221092125