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- Title
Phytochemical composition, and analgesic and antiinflammatory properties of essential oil of Chamaemelum nobile (Asteraceae L All) in rodents.
- Authors
Aremu, Olukayode O.; Tata, Charlotte M.; Sewani-Rusike, Constance R.; Oyedeji, Adebola O.; Oyedeji, Opeoluwa O.; Nkeh-Chungag, Benedicta N.
- Abstract
Purpose: To investigate the in vivo analgesic and anti-inflammatory activities of essential oil of dried flowers of Chamaemelum nobile (Asteraceae L. All) in Swiss mice and Wistar rats, respectively. Methods: The volatile oil of the dried flowers of C. nobile obtained by hydrodistillation was analyzed by gas chromatography-mass spectrometry (GC-MS). Animals were assigned to the following experimental groups: C. nobile (180 mg/kg), ibuprofen (100 mg/kg) and vehicle-treated groups. Chemical and thermal pain models were used for the antinociceptive study in mice while fresh egg albumin-induced acute inflammation model in rats was used for anti-inflammatory study of the essential oil. Results: The most abundant components of the oil were a-bisabolol (50%) and farnesene (5.35%). Oral administration of essential oil (180 mg/kg, po) significantly (p < 0.05) reduced pain and prevented inflammation in the different test models used in this study. Conclusion: The essential oil of the dried flowers of C. nobile shows in vivo analgesic and antiinflammatory activities in rodents, and therefore, possesses potentials for development into effective analgesic and anti-inflammatory agent.
- Subjects
ANALGESICS; ANTIARTHRITIC agents; ANTI-inflammatory agents; ESSENTIAL oils; GAS chromatography/Mass spectrometry (GC-MS)
- Publication
Tropical Journal of Pharmaceutical Research, 2018, Vol 17, Issue 10, p1939
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v17i10.7