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- Title
Inverse Gottron's sign in anti-MDA5 dermatomyositis.
- Authors
Suda, T
- Abstract
This article discusses a case of a 65-year-old woman who was admitted to the hospital after an abnormal shadow was found on her chest X-ray. The patient was diagnosed with anti-MDA5 dermatomyositis, a condition characterized by rapidly progressive interstitial pneumonitis. The presence of a keratotic papule on the flexor side of the finger, known as 'inverse Gottron's sign', strongly indicates the presence of anti-MDA5 antibody-positive. The article also mentions that the clinical presentation of this condition can vary based on geographical location and ethnic background. In Asian populations, particularly Japanese, the incidence of rapid progressive interstitial pneumonia in anti-MDA5 antibody-positive myositis is high, and the mortality rate is also significant. The patient in this case did not respond to treatment and eventually died.
- Subjects
DERMATOMYOSITIS; PULMONARY fibrosis; ASYMPTOMATIC patients
- Publication
QJM: An International Journal of Medicine, 2024, Vol 117, Issue 3, p213
- ISSN
1460-2725
- Publication type
Article
- DOI
10.1093/qjmed/hcad250