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- Title
Effect of PPAR-ϒ Agonist Treatment on Markers of Endothelial Dysfunction in Patients with Type 2 Diabetes Mellitus.
- Authors
DoleŽalová, R.; Haluzík, M. M.; Bošanská, L.; Lacinová, Z.; Kasalová, Z.; Štulc, T.; Haluzík, M.
- Abstract
Thiazolidinediones are insulin-sensitizing drugs acting through peroxisome proliferator-activated receptor (PPAR)- γ. The aim of our study was to evaluate the effect of 5-month treatment with PPAR- γ agonist - rosiglitazone (4 mg/day), on the circulating markers of endothelial dysfunction and to evaluate the role of changes in endocrine function of adipose tissue in this process. Biochemical and metabolic parameters, circulating adiponectin, resistin, ICAM-1, VCAM-1, E-selectin, P-selectin, PAI-1, myeloperoxidase (MPO), and matrix metalloproteinase-9 (MMP-9) concentrations were assessed in 10 women with type 2 DM before and after rosiglitazone treatment and in a control group of healthy women. At baseline, diabetic group had significantly higher serum concentrations of glucose, glycated hemoglobin, V-CAM and PAI-1 compared to control group. Adiponectin levels tended to be lower in diabetic group, while resistin concentrations did not differ from control group. Rosiglitazone treatment improved diabetes compensation, significantly reduced VCAM-1, PAI-1 and E-selectin concentrations and increased adiponectin levels, while it did not affect serum resistin concentrations. Adiponectin concentrations at baseline were inversely related to E-selectin and MPO levels, this correlation disappeared after rosiglitazone treatment. We conclude that 5-month rosiglitazone treatment significantly reduced several markers of endothelial dysfunction. This effect could be at least in part attributable to marked increase of circulating adiponectin levels.
- Subjects
TYPE 2 diabetes; PATIENTS; CARDIOVASCULAR diseases risk factors; HORMONES; FAT cells; ADIPOSE tissues
- Publication
Physiological Research, 2007, Vol 56, Issue 6, p741
- ISSN
0862-8408
- Publication type
Article
- DOI
10.33549/physiolres.931060