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- Title
Presynaptic long-term potentiation requires extracellular signal-regulated kinases in the anterior cingulate cortex.
- Authors
Chen, Qi-Yu; Zhang, Zhi-Ling; Liu, Qin; Chen, Chao-Jun; Zhang, Xiao-Kang; Xu, Ping-Yi; Zhuo, Min
- Abstract
Extracellular signal-regulated kinases are widely expressed protein kinases in neurons, which serve as important intracellular signaling molecules for central plasticity such as long-term potentiation. Recent studies demonstrate that there are two major forms of long-term potentiation in cortical areas related to pain: postsynaptic long-term potentiation and presynaptic long-term potentiation. In particular, presynaptic long-term potentiation in the anterior cingulate cortex has been shown to contribute to chronic pain-related anxiety. In this review, we briefly summarized the components and roles of extracellular signal-regulated kinases in neuronal signaling, especially in the presynaptic long-term potentiation of anterior cingulate cortex, and discuss the possible molecular mechanisms and functional implications in pain-related emotional disorders.
- Subjects
EXTRACELLULAR signal-regulated kinases; LONG-term potentiation; CINGULATE cortex; PROTEIN kinases; SYNAPTOPHYSIN; MITOGEN-activated protein kinases
- Publication
Molecular Pain, 2020, Vol 16, p1
- ISSN
1744-8069
- Publication type
Article
- DOI
10.1177/1744806920917245