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- Title
Lipoaspirate Injection in Relapsing Idiopathic Subglottic Stenosis: Preliminary Results.
- Authors
Mattioli, Francesco; Serafini, Edoardo; Andreani, Alessandro; Cappiello, Gaia; De Maria, Federico; Marchioni, Daniele; Pinelli, Massimo; Marchioni, Alessandro
- Abstract
Objectives: The management of idiopathic subglottic stenosis (iSGS) poses a clinical challenge due to high recurrence rates following both endoscopic and open approaches, often leading to tracheostomy. The activation of abnormal T-cells and cytokine pathways has been linked to iSGS pathogenesis. Autologous adipose tissue centrifugation yields lipoaspirate, offering optimal anti-inflammatory effects and biocompatibility widely utilized in various medical settings. This report presents the first 3 cases employing endoscopic dilation (ED) in combination with local lipoaspirate injection to address recurrent iSGS. Methods: A prospective observational study was conducted, involving multidisciplinary evaluation by the Tracheal Team at the University of Modena. Patients meeting specific criteria were directed to undergo ED + lipoaspirate injection. Results: Three patients fulfilled the inclusion criteria. The mean number of prior endoscopic procedures performed was 8. Endoscopic examination revealed 90% stenosis in patient A, 60% stenosis in patient B, and 60% stenosis in patient C. All patients presented inflammatory tissue or incipient granulations at the stenotic site, with an average time of 6 months between previous procedures. After 15 months, none of the patients required further procedures, and endoscopic examination revealed a significant reduction or disappearance of inflammatory tissue with a stable airway lumen. Conclusions: The observed results are encouraging in terms of reducing local inflammation and halting stenosis progression, especially in cases of short-term relapsing iSGS.
- Subjects
TRACHEOTOMY; ANTI-inflammatory agents; T cells; ADIPOSE tissues; DISEASE management; SCIENTIFIC observation; TRACHEOBRONCHOMALACIA; ENDOSCOPIC surgery; TRACHEA; LONGITUDINAL method; GRANULATION tissue; DISEASE relapse; CYTOKINES; GLOTTIS; ENDOSCOPY; HEALTH care teams; DISEASE progression
- Publication
Annals of Otology, Rhinology & Laryngology, 2024, Vol 133, Issue 6, p618
- ISSN
0003-4894
- Publication type
Article
- DOI
10.1177/00034894241237021