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- Title
Levels of plasma sulfatides C18 : 0 and C24 : 1 correlate with disease status in relapsing-remitting multiple sclerosis.
- Authors
Moyano, Ana L; Pituch, Katarzyna; Li, Guanan; Breemen, Richard; Mansson, Jan E; Givogri, Maria I
- Abstract
Multiple sclerosis ( MS) is considered an autoimmune demyelinating disease of the CNS and myelin-derived glycolipids are one of the targets of this autoimmune attack. In this study, we examined for the first time the plasma distribution of sulfatide isoforms. Sulfatides with long-chain (C24 : 0 or C24 : 1) and short-chain (C16 : 0 or C18 : 0) fatty acids were quantified in plasma of relapsing-remitting MS patients by ultra-high-performance liquid chromatography tandem mass spectrometry. We found that C18 : 0 and C24 : 1 sulfatide plasma levels positively correlated with the Expanded Disability Status Scale. C16/C18 : 0 and C16/C24 : 0 ratios also correlated with the age and the time since last relapse. Healthy women showed higher levels of C16 : 0 sulfatide than healthy men; however, this gender difference disappeared in MS patients. Our data underline the potential use of sulfatides as biomarkers in relapsing-remitting MS and points to a possible association with the higher susceptibility of women to develop MS.
- Subjects
SULFATIDES; STATISTICAL correlation; DISEASE relapse; MULTIPLE sclerosis; AUTOIMMUNE diseases; DEMYELINATION; CENTRAL nervous system diseases
- Publication
Journal of Neurochemistry, 2013, Vol 127, Issue 5, p600
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1111/jnc.12341