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- Title
Two seasons' experience with pandemic A H1N1 influenza infection in neonates.
- Authors
Martic, Jelena; Savic, Natasa; Jankovic, Borisav; Nedeljkovic, Jasminka; Rakonjac, Zorika; Pejic, Katarina; Markovic-Sovtic, Gordana
- Abstract
There are only a few reports on influenza A H1N1 infection in neonates. In this paper, we present our additional experience on the clinical characteristics, epidemiology and treatment of influenza A H1N1 (2009) infection in 10 newborn infants (aged 9-24 days). Influenza A H1N1 infection was confirmed by real-time reverse transcription-polymerase chain reaction of the nasopharyngeal swab specimens. The majority of neonates presented with fever, respiratory symptoms and lethargy. The respiratory illness ranged from mild symptoms to severe pneumonia requiring mechanical ventilation. Antiviral treatment with oseltamivir was started in five patients (50%). One lethal outcome was observed, while nine patients (90%) had complete recovery. To our knowledge, this is the largest presented series of neonatal cases with different clinical symptoms. We discuss the necessity of initiation of oseltamivir in infants with different clinical features.
- Subjects
NEONATAL diseases; H1N1 influenza; REVERSE transcriptase polymerase chain reaction; OSELTAMIVIR; RESPIRATORY infections; SYMPTOMS; H1N1 2009 influenza epidemiology; DIAGNOSIS
- Publication
Turkish Journal of Pediatrics, 2012, Vol 54, Issue 6, p612
- ISSN
0041-4301
- Publication type
Article