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- Title
The Q/E27 polymorphism in the beta2-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins.
- Authors
Ehrenborg, E; Skogsberg, J; Ruotolo, G; Large, V; Eriksson, P; Arner, P; Hamsten, A
- Abstract
<bold>Objectives: </bold>To investigate whether a substitution of glutamine by glutamic acid at amino acid position 27 (Q/E27) and an arginine to glycine transition at amino acid 16 (R/G16) in the beta2-adrenoceptor gene are associated with lipid and lipoprotein disturbances and/or increased body weight in men.<bold>Design: </bold>Population-based study.<bold>Setting: </bold>Department of medicine at a university hospital.<bold>Subjects: </bold>A total of 180 healthy men, aged 30-45 years, were recruited at random from a register containing all permanent residents in Stockholm County (response rate of 70%).<bold>Main Outcome Measures: </bold>Frequency of beta2-adrenoceptor genotypes and alleles in relation to plasma lipid and lipoprotein levels and body mass index.<bold>Results: </bold>Individuals carrying the E27 allele and/or the G16 allele had significantly higher body mass index (BMI). Furthermore, carriers of the E27 allele had significantly higher plasma concentrations of cholesterol, triglycerides, VLDL cholesterol and VLDL triglycerides than did subjects homozygous for the Q allele.<bold>Conclusion: </bold>The E27 allele of the beta2-adrenoceptor gene is associated with slightly to moderately elevated BMI and dyslipoproteinaemia involving triglyceride-rich lipoproteins in healthy younger and middle-aged men.
- Subjects
SWEDEN; ALLELES; ARGININE; BODY weight; CELL receptors; CHOLESTEROL; COMPARATIVE studies; GENETIC polymorphisms; GLUTAMIC acid; GLUTAMINE; GLYCINE; HYPERLIPOPROTEINEMIA; LOW density lipoproteins; RESEARCH methodology; MEDICAL cooperation; GENETIC mutation; RESEARCH; TRIGLYCERIDES; EVALUATION research; GENOTYPES
- Publication
Journal of Internal Medicine, 2000, Vol 247, Issue 6, p651
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2000.00669.x