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- Title
Thermoregulation.
- Authors
Rowsey, Pamela Johnson
- Abstract
The study of fever has provided important models in understanding the cells, chemical messengers, and anatomic structures that are involved in inflammation and thermoregulation as a result of infection, stress, or trauma. After contact with a pathogen or an inflammatory stimulus, cells are activated to produce endogenous pyrogens called cytokines. Cytokine functions include a cascade of nonspecific immune responses by target leukocytes and reticuloendothelial cells inducing the synthesis of acute phase proteins by the liver, direct pyrogenic activities via the supraoptic nuclei and the hypothalamus to increase the thermoregulatory set-point (and, thus, induce fever), and a wide spectrum of additional immune effects.
- Subjects
BLOOD-brain barrier; BODY temperature regulation; CORTICOTROPIN releasing hormone; EXERCISE; FEVER; INFECTION; INFLAMMATION; INTERFERONS; INTERLEUKINS; MATHEMATICAL models; PSYCHOLOGICAL stress; TUMOR necrosis factors; THEORY
- Publication
Annual Review of Nursing Research, 2013, Vol 31, p19
- ISSN
0739-6686
- Publication type
Article
- DOI
10.1891/0739-6686.31.19