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- Title
Zα Domain of Goldfish PKR-like Protein Kinase Exhibits the Flexible Backbone Structure of β-Hairpin for Efficient Z- DNA Binding.
- Authors
Lee, Jin-Young; Lee, Ae-Ree; Choi, Seo-Ree; Seo, Yeo-Jin; Lee, Shim Sung; Lee, Joon-Hwa
- Abstract
The article presents a study of goldfish RNA-dependent protein kinase (PKR). The research performed NMR backbone dynamics experiments on the free goldfish PKR and PKR-dT(CG)3 complex to examine the structural and dynamic properties of goldfish PKR when it induces the B-Z transition in a DNA duplex. Results of the study found that goldfish PKR showed a unique dynamics feature of the beta-hairpin for efficient Z-DNA binding.
- Subjects
GOLDFISH; SPINE; PROTEIN kinases; Z-DNA; RNA; HAIRPIN (Genetics); GENETIC translation
- Publication
Bulletin of the Korean Chemical Society, 2016, Vol 37, Issue 9, p1526
- ISSN
0253-2964
- Publication type
Article
- DOI
10.1002/bkcs.10881