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- Title
SNAP-25 in Neuropsychiatric Disorders.
- Authors
Corradini, Irene; Verderio, Claudia; Sala, Mariaelvina; Wilson, Michael C.; Matteoli, Michela
- Abstract
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.
- Subjects
CELL membranes; PROTEINS; PATHOLOGICAL psychology; MENTAL illness; EXOCYTOSIS; CELL physiology; CYTOLOGY; BIOLOGY; CALCIUM channels
- Publication
Annals of the New York Academy of Sciences, 2009, Vol 1152, p93
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2008.03995.x