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- Title
Transforming Growth Factor--β Regulates Susceptibility of Epithelial Apoptosis in Murine Model of Colitis.
- Authors
SAKURABA, HIROTAKE; ISHIGURO, YOH; YAMAGATA, KAZUFUMI; TAGAWA, YOH‐ICHI; IWAKURA, YOICHIRO; SEKIKAWA, KENJI; MUNAKATA, AKIHIRO; NAKANE, AKIO
- Abstract
Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSSinduced colitis.
- Subjects
EPITHELIAL cells; PHYSIOLOGICAL control systems; APOPTOSIS; ANTINEOPLASTIC agents; COLON diseases
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1029, Issue 1, p382
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1309.044