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- Title
Brivaracetam: How Well Does It Fare as an Anti-Epileptic? A Review.
- Authors
Khilari, Madhuri; Nair, Pradeep; Jha, Brajesh; Nair, Pradeep P; Jha, Brajesh Kumar
- Abstract
<bold>Objectives: </bold>Epilepsy is a common neurological ailment contributing to significant disability. About one-third of all epilepsy patients would be refractory to two or more medications. Brivaracetam (BRV) is one of the newer anti-seizure medications on which extensive data is available, but its efficacy as an early add-on agent (first/second adjuvant) is unclear. The principal objective of this review is to assess the efficacy of BRV as an early add-on agent in refractory Focal Onset Seizures (FOS) and its pharmacology and usage in various clinical situations associated with seizures.<bold>Methods: </bold>We searched two databases, Medline and Cochrane Central, for papers on BRV and FOS, and selected six studies with randomized parallel control design to extract the data for a meta-analysis. We also did a comprehensive review of the available literature on its pharmacology and usage in various clinical scenarios associated with seizures.<bold>Results: </bold>For the meta-analysis, we extracted 145 articles; six studies fulfilled the selection criteria that gave us data on 1938 patients who received Brivaracetam as an early add-on agent in FOS. The Risk Ratio (RR) (95% CI) for 50% responders across the trials was 1.88 (1.55-2.29). Similarly, the overall RR (95% CI) was 5.82 (2.15-15.70) for seizure freedom.<bold>Conclusion: </bold>Our analysis provides moderate evidence for Brivaracetam as an effective agent as an early adjuvant in FOS. Its efficacy for several other indications needs further clinical trials and evaluation.
- Subjects
SEIZURES (Medicine); ANTICONVULSANTS; PEOPLE with epilepsy; EPILEPSY; DATABASE searching; COMBINATION drug therapy; META-analysis; HETEROCYCLIC compounds; SYSTEMATIC reviews
- Publication
Neurology India, 2021, Vol 69, Issue 2, p284
- ISSN
0028-3886
- Publication type
journal article
- DOI
10.4103/0028-3886.314584