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- Title
High-Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO<sub>2</sub> Heterogeneous Catalyst.
- Authors
Kovtunov, Kirill V.; Barskiy, Danila A.; Coffey, Aaron M.; Truong, Milton L.; Salnikov, Oleg G.; Khudorozhkov, Alexander K.; Inozemtseva, Elizaveta A.; Prosvirin, Igor P.; Bukhtiyarov, Valery I.; Waddell, Kevin W.; Chekmenev, Eduard Y.; Koptyug, Igor V.
- Abstract
Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D 1H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm3) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.
- Subjects
HIGH resolution imaging; PROTON magnetic resonance; PARAHYDROGEN; RHODIUM catalysts; TITANIUM oxides; HETEROGENEOUS catalysts
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 37, p11636
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403604