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- Title
Unprecedented High-Nuclear Transition-Metal-Cluster-Substituted Heteropolyoxoniobates: Synthesis by {V<sub>8</sub>} Ring Insertion into the POM Matrix and Antitumor Activities.
- Authors
Shen, Jian‐Qiang; Wu, Qiong; Zhang, Ying; Zhang, Zhi‐Ming; Li, Yang‐Guang; Lu, Ying; Wang, En‐Bo
- Abstract
Reactions of hexaniobate with vanadate in the presence of Ni2+, Zn2+, or Cu2+ have furnished three high-nuclear vanadium cluster-substituted heteropolyoxoniobates (HPNs): {Ni(en)3}5H{VVNb8VIV8O44} ⋅9 H2O ( 1), (H2en)Na2[{Zn(en)2(Hen)}{Zn(en)2(H2O)}2{PNb8VIV8O44}] ⋅11 H2O ( 2), and Na{Cu(en)2}3{[Cu(en)2]2[PNb8VIV8O44]} ⋅11 H2O ( 3) (en=1,2-diaminoethane). Their structures have been determined and characterized by single-crystal X-ray diffraction analysis, thermogravimetric analysis (TGA), and elemental analysis. Structural analysis has revealed that compounds 1- 3 contain similar {V8}-substituted [XVNb8VIV8O44]11− (X=P, V) clusters, obtained by inserting a {V8} ring into tetravacant HPN [XNb8O36]27−. To the best of our knowledge, compounds 1- 3 represent the first high-nuclear vanadium cluster-substituted HPNs, and compound 1 is the largest vanadoniobate cluster yet obtained in HPN chemistry. Nickel and zinc cations have been introduced into HPNs for the first time, which might promise a more diverse set of structures in this family. Antitumor studies have indicated that compounds 1 and 2 exhibit high activity against human gastric cancer SGC-7901 cells, SC-1680 cells, and MG-63 cells.
- Subjects
METAL clusters; INSERTION reactions (Chemistry); ANTINEOPLASTIC agents; VANADIUM compounds; X-ray diffraction
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 10, p2840
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201303995