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- Title
In Situ Self‐Aggregation of Spirulina Skeleton Fibers Enhances the Efficacy of Anti‐Tumor Thermal Immunotherapy.
- Authors
Qi, Yong‐Dan; Zhuang, Ze‐Nan; Zeng, Si‐Min; Tang, Ying; Cheng, Han; Cheng, Si‐Xue; Zhang, Xian‐Zheng
- Abstract
The lack of broad‐spectrum tumor antigens, limited immunogenicity of antigens, and immunosuppressive microenvironment in tumors have impeded the development of cancer vaccines. To address this issue, a vaccine platform is developed based on Spirulina skeleton fibers loaded with gold (Au) nanoparticles (Au@E‐SP). Upon subcutaneous administration, Au@E‐SP self‐aggregates in situ and forms a 3D vaccine scaffold owing to its elongated and helical architecture. Through the aggregation of Au@E‐SP, Au nanoparticles are concentrated, which significantly enhances the local photothermal effect and releases more tumor‐associated antigens. In addition, the retained E‐SP serves as a natural immune adjuvant that sustainably reverses the immunosuppressive microenvironment in vivo. Combining these advantages, the vaccines induce a potent anti‐tumor immune response, effectively inhibiting tumor recurrence and metastasis. This strategy utilizes microalgae as a self‐adjuvant vaccine, providing a promising avenue for further research in tumor immunotherapy.
- Subjects
SPIRULINA; IMMUNOTHERAPY; PHOTOTHERMAL effect; GOLD nanoparticles; TUMOR antigens; IMMUNOGLOBULINS; DENDRITIC cells
- Publication
Advanced Functional Materials, 2024, Vol 34, Issue 19, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202312201