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- Title
Acute Extrapyramidal Reactions Following Lithium and Sulpiride Co-administration: Two Case Reports.
- Authors
Dinan, Timothy G.; O'Keane, Veronica
- Abstract
Two case reports are presented in which lithium and sulpiride were used jointly in patients with affective disorder. In both cases significant extrapyramidal reactions occurred. The reactions were successfully treated by withdrawing the drug combination. II is suggested that the adverse events relate to the mechanism of action of sulpiride which, unlike other neuroleptics, requires sodium to hind to the dopamine receptor. Lithium may substitute for sodium-enhancing sulpiride binding.
- Subjects
AFFECTIVE disorders; CATECHOLAMINES; NEUROTRANSMITTERS; LITHIUM; SODIUM; ANTIPSYCHOTIC agents
- Publication
Human Psychopharmacology: Clinical & Experimental, 1991, Vol 6, Issue 1, p67
- ISSN
0885-6222
- Publication type
Article
- DOI
10.1002/hup.470060112