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- Title
Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age.
- Authors
Miyashita, Naoyuki; Maruyama, Takaya; Kobayashi, Tetsu; Kobayashi, Hiroyasu; Taguchi, Osamu; Kawai, Yasuhiro; Yamaguchi, Tetsuya; Ouchi, Kazunobu; Oka, Mikio
- Abstract
macrolide-resistant Mycoplasma pneumoniae strain was isolated from two patients with community-acquired pneumonia. The pneumonia severity score of both patients was mild, and rapid clinical improvement was seen after administration of fluoroquinolone. Clinical features of macrolide-resistant M. pneumoniae pneumonia were identical to those of macrolide-sensitive M. pneumoniae pneumonia. An A-to-G transition at position 2063 and 2064, respectively, in domain V of the 23S rRNA gene was identified. The minimum inhibitory concentration of erythromycin of these isolates was greatly elevated. In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults.
- Subjects
MYCOPLASMA pneumoniae; MACROLIDE antibiotics; COMMUNITY-acquired pneumonia; ANTIBACTERIAL agents; JUVENILE diseases
- Publication
Journal of Infection & Chemotherapy (Springer Science & Business Media B.V.), 2011, Vol 17, Issue 1, p114
- ISSN
1341-321X
- Publication type
Article
- DOI
10.1007/s10156-010-0093-1