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- Title
Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position.
- Authors
Tolan, Dina A.; Abdel‐Monem, Yasser K.; El‐Nagar, Mohamed A.
- Abstract
The role of inflammation in cancer generation is gaining importance in the field of cancer research. The chemo‐anti‐inflammatory strategy that involves using non‐steroidal anti‐inflammatory drug compounds as effective anti‐tumor agents is being acceded globally. In the present study, seven new Pt (IV) complexes based on cisplatin, carboplatin and oxaliplatin scaffold bearing the anti‐inflammatory drug naproxen in the axial position were synthesized and characterized by elemental analysis, ESI‐MS, Fourier transform‐infrared, 1H‐ and 195Pt‐NMR spectroscopy. The reduction behavior in the presence of ascorbic acid was studied using high‐performance liquid chromatography. The cytotoxicity against two human breast cell lines and the anti‐inflammatory properties were evaluated. All the complexes are able to promote a comparable activity, with average three‐ and 13‐fold more cytotoxic than cisplatin against MCF7 and MDA‐MB‐231 cell lines, respectively. The complexes show remarkable anti‐inflammatory effects, which indicated their potential in treating cancer associated with inflammation and reducing side‐effects of chemotherapy. The synthesis and anti‐tumor activity of seven platinum (IV) complexes based on cisplatin, oxaliplatin and carboplatin scaffolds with the anti‐inflammatory drug naproxen as axial ligand are reported.
- Subjects
ANTINEOPLASTIC agents; PLATINUM compounds; METAL complexes; ANTI-inflammatory agents; NAPROXEN; CANCER treatment
- Publication
Applied Organometallic Chemistry, 2019, Vol 33, Issue 3, pN.PAG
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.4763