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- Title
Reproducibility of native T<sub>1</sub> mapping for renal tissue characterization at 3T.
- Authors
Dekkers, Ilona A.; Paiman, Elisabeth H.M.; Vries, Aiko P.J.; Lamb, Hildo J.; de Vries, Aiko P J
- Abstract
<bold>Background: </bold>Advanced renal disease is characterized by adverse changes in renal structure; however, noninvasive techniques to diagnose and monitor these changes are currently lacking.<bold>Purpose: </bold>To evaluate the reproducibility of native T1 mapping for renal tissue characterization.<bold>Study Type: </bold>Reproducibility study.<bold>Population: </bold>Fifteen healthy volunteers (mean age 31 years, range 19-63 years), and 11 patients with diabetic nephropathy (mean age 57 years, range 51-69 years).<bold>Field Strength/sequence: </bold>3T, modified Look-Locker imaging (MOLLI) 5(3)3.<bold>Assessment: </bold>Intra- and interexamination reproducibility of voxel-based T1 relaxation times of renal cortex and medulla was assessed in healthy human volunteers and diabetic nephropathy patients.<bold>Statistical Tests: </bold>Reproducibility was evaluated using Bland-Altman and intraclass correlation coefficients (ICCs).<bold>Results: </bold>Intra- and interexamination reproducibility of renal native T1 mapping showed good-strong ICCs (0.83-0.89) for renal cortex and medulla, and moderate-good ICCs (0.62-0.81) for cortex-medulla ratio in both healthy volunteers and diabetic nephropathy patients. Intra- and interexamination limits of agreement were respectively (-124 msec, + 82 msec) and (-134 msec, + 98 msec) for renal cortex and (-138 msec, + 107 msec) and (-118 msec, + 151 msec) for medulla. Overall T1 values for renal cortex (P = 0.277) and medulla (P = 0.973) were not significantly different between healthy volunteers and diabetic nephropathy patients, in contrast to the cortex-medulla ratio (P = 0.003).<bold>Data Conclusion: </bold>Renal native T1 mapping is a technique with good-strong intra- and examination reproducibility in both healthy volunteers and diabetic nephropathy patients.<bold>Level Of Evidence: </bold>3 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;49:588-596.
- Publication
Journal of Magnetic Resonance Imaging, 2019, Vol 49, Issue 2, p588
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.26207