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- Title
Intravoxel incoherent motion MRI in differentiation between recurrent carcinoma and postchemoradiation fibrosis of the skull base in patients with nasopharyngeal carcinoma.
- Authors
Mao, Jiaji; Shen, Jun; Yang, Qihua; Yu, Taihui; Duan, Xiaohui; Zhong, Jinglian; Phuyal, Prakash; Liang, Biling
- Abstract
<bold>Purpose: </bold>To determine the capacity of intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) in differential diagnosis between recurrent carcinoma and postchemoradiation fibrosis of skull base in patients with nasopharyngeal carcinoma (NPC).<bold>Materials and Methods: </bold>Eleven patients with recurrent NPC and 21 patients with postchemoradiation fibrosis in the skull base were enrolled. All the diagnoses were proved by endoscopic biopsy or imaging follow-up. IVIM MRI was performed to obtain quantitative parameters including D (pure diffusion), f (perfusion fraction), and D* (pseudodiffusion). D, f, and D* were compared between two groups; the diagnostic performances of D and f were evaluated using the receiver operating characteristic (ROC) analysis.<bold>Results: </bold>D and f values were significantly lower in recurrent carcinoma than that in fibrosis (P < 0.001; P = 0.001). No significant difference was found in D* values between recurrent carcinoma and fibrosis (P = 0.229). ROC curve analysis showed that the area under the curve of D and f values were 0.996 and 0.838, respectively. Respective cutoff values with sensitivity, specificity, and accuracy were: D = 1.161 × 10-3 mm2 /s (sensitivity 100.0%, specificity 95.2%, accuracy 96.9%), f = 0.109 (sensitivity 81.8%, specificity 71.4%, accuracy 75.0%).<bold>Conclusion: </bold>Recurrent NPC and postchemoradiation fibrosis in the skull base have distinctive D and f values. IVIM MRI could be used to differentiate between recurrent carcinoma and postchemoradiation fibrosis in patients with NPC. J. Magn. Reson. Imaging 2016;44:1556-1564.
- Subjects
CANCER treatment; CANCER; CANCER relapse; CLINICAL trials; COMPARATIVE studies; DIAGNOSTIC imaging; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; COMPUTERS in medicine; MOTION; NASOPHARYNX tumors; RESEARCH; RESEARCH evaluation; SKULL; EVALUATION research; FIBROSIS; TREATMENT effectiveness; TUMOR treatment; PREVENTION
- Publication
Journal of Magnetic Resonance Imaging, 2016, Vol 44, Issue 6, p1556
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25302