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- Title
T<sub>2</sub> Relaxation time quantitation differs between pulse sequences in articular cartilage.
- Authors
Matzat, Stephen J.; McWalter, Emily J.; Kogan, Feliks; Chen, Weitian; Gold, Garry E.
- Abstract
Background To compare T2 relaxation time measurements between MR pulse sequences at 3 Tesla in agar phantoms and in vivo patellar, femoral, and tibial articular cartilage. Methods T2 relaxation times were quantified in phantoms and knee articular cartilage of eight healthy individuals using a single echo spin echo (SE) as a reference standard and five other pulse sequences: multi-echo SE (MESE), fast SE (2D-FSE), magnetization-prepared spoiled gradient echo (3D-MAPSS), three-dimensional (3D) 3D-FSE with variable refocusing flip angle schedules (3D vfl-FSE), and quantitative double echo steady state (qDESS). Cartilage was manually segmented and average regional T2 relaxation times were obtained for each sequence. A regression analysis was carried out between each sequence and the reference standard, and root-mean-square error (RMSE) was calculated. Results Phantom measurements from all sequences demonstrated strong fits (R2 > 0.8; P < 0.05). For in vivo cartilage measurements, R2 values, slope, and RMSE were: MESE: 0.25/0.42/5.0 ms, 2D-FSE: 0.64/1.31/9.3 ms, 3D-MAPSS: 0.51/0.66/3.8 ms, 3D vfl-FSE: 0.30/0.414.2 ms, qDESS: 0.60/0.90/4.6 ms. Conclusion 2D-FSE, qDESS, and 3D-MAPSS demonstrated the best fits with SE measurements as well as the greatest dynamic ranges. The 3D-MAPSS, 3D vfl-FSE, and qDESS demonstrated the closest average measurements to SE. Discrepancies in T2 relaxation time quantitation between sequences suggest that care should be taken when comparing results between studies. J. Magn. Reson. Imaging 2015;42:105-113. © 2014 Wiley Periodicals, Inc.
- Publication
Journal of Magnetic Resonance Imaging, 2015, Vol 42, Issue 1, p105
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.24757