We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Quantitative assessment of cardiac output and left ventricular function by noninvasive phase-contrast and cine MRI: Validation study with invasive pressure-volume loop analysis in a swine model.
- Authors
Lin, Hung-Yu; Freed, Darren; Lee, Trevor W.R.; Arora, Rakesh C.; Ali, Ayyaz; Almoustadi, Waiel; Xiang, Bo; Wang, Fei; Large, Stephen; King, Scott B.; Tomanek, Boguslaw; Tian, Ganghong
- Abstract
Purpose: To validate noninvasive cardiac output measurements of phase-contrast magnetic resonance imaging (PC-MRI) and cine MRI using an invasive pressure-volume (PV) loop technique on a swine model. Materials and Methods: We compared three methods for evaluating cardiac function at rest and under pharmaceutical low-dose inotropic infusion conditions: 1) phase-contrast MRI, 2) cine MRI, and 3) PV loop relationship. These measurements were made in 14 domestic pigs under rest conditions. Identical MRI acquisitions and PV loop analysis were performed on six pigs from the same group that received an infusion of dobutamine 2.5 μg/kg/min. Cardiac outputs from all measurements were analyzed and compared using linear regression and Bland-Altman analysis. Results: Noninvasive PC-MRI and cine MRI did not show any significant differences compared to an invasive PV loop technique for measurement of cardiac output under both rest (PC-MRI, cine MRI, and PV loop, 3.17 ± 0.45, 3.18 ± 0.61, 3.45 ± 0.41 L/min, respectively) and pharmaceutical low-dose inotropic infusion conditions (PC-MRI, cine MRI, and PV loop, 4.78 ± 0.53, 4.7 ± 0.6, 4.96 ± 0.48 L/min, respectively). Statistical analysis showed good agreement of cardiac output measurements at rest ( R
- Publication
Journal of Magnetic Resonance Imaging, 2011, Vol 34, Issue 1, p203
- ISSN
1053-1807
- Publication type
Article
- DOI
10.1002/jmri.22587