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- Title
An Update on Development of Small-Molecule Plasmodial Kinase Inhibitors.
- Authors
Moolman, Chantalle; Sluis, Rencia van der; Beteck, Richard M.; Legoabe, Lesetja J.
- Abstract
Malaria control relies heavily on the small number of existing antimalarial drugs. However, recurring antimalarial drug resistance necessitates the continual generation of new antimalarial drugs with novel modes of action. In order to shift the focus from only controlling this disease towards elimination and eradication, next-generation antimalarial agents need to address the gaps in the malaria drug arsenal. This includes developing drugs for chemoprotection, treating severe malaria and blocking transmission. Plasmodial kinases are promising targets for next-generation antimalarial drug development as they mediate critical cellular processes and some are active across multiple stages of the parasite's life cycle. This review gives an update on the progress made thus far with regards to plasmodial kinase small-molecule inhibitor development.
- Subjects
KINASE inhibitors; PARASITE life cycles; ANTIMALARIALS; DISEASE eradication; IVERMECTIN; DRUG development
- Publication
Molecules, 2020, Vol 25, Issue 21, p5182
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25215182