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- Title
Serjanic Acid Improves Immunometabolic Markers in a Diet-Induced Obesity Mouse Model.
- Authors
Gutiérrez, Gustavo; Giraldo-Dávila, Deisy; Combariza, Marianny Y.; Holzgrabe, Ulrike; Tabares-Guevara, Jorge Humberto; Ramírez-Pineda, José Robinson; Acín, Sergio; Muñoz, Diana Lorena; Montoya, Guillermo; Balcazar, Norman
- Abstract
Plant extracts from Cecropia genus have been used by Latin-American traditional medicine to treat metabolic disorders and diabetes. Previous reports have shown that roots of Cecropia telenitida that contains serjanic acid as one of the most prominent and representative pentacyclic triterpenes. The study aimed to isolate serjanic acid and evaluate its effect in a prediabetic murine model by oral administration. A semi-pilot scale extraction was established and serjanic acid purification was followed using direct MALDI-TOF analysis. A diet induced obesity mouse model was used to determine the impact of serjanic acid over selected immunometabolic markers. Mice treated with serjanic acid showed decreased levels of cholesterol and triacylglycerols, increased blood insulin levels, decreased fasting blood glucose and improved glucose tolerance, and insulin sensitivity. At transcriptional level, the reduction of inflammation markers related to adipocyte differentiation is reported.
- Subjects
BLOOD sugar; PLANT extracts; INSULIN resistance; METABOLIC disorders; OBESITY
- Publication
Molecules, 2020, Vol 25, Issue 7, p1486
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25071486