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- Title
Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria.
- Authors
Lin, Fengming; Bao, Yan-Wen; Wu, Fu-Gen; Reed, Scott; Lee, Jung-Jae
- Abstract
Mitochondria-targeted cancer phototherapy (PT), which works by delivering photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the phototherapeutic efficiency of anticancer treatments. Mitochondria play an essential role in cellular apoptosis, and are relevant to the chemoresistance of cancer cells. Furthermore, mitochondria are a major player in many cellular processes and are highly sensitive to hyperthermia and reactive oxygen species. Therefore, mitochondria serve as excellent locations for organelle-targeted phototherapy. In this review, we focus on the recent advances of mitochondria-targeting materials for mitochondria-specific PT. The combination of mitochondria-targeted PT with other anticancer strategies is also summarized. In addition, we discuss both the challenges currently faced by mitochondria-based cancer PT and the promises it holds.
- Subjects
MITOCHONDRIA; ANTINEOPLASTIC agents; APOPTOSIS; REACTIVE oxygen species; FEVER
- Publication
Molecules, 2018, Vol 23, Issue 11, p3016
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23113016