We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of A Polyphenol-Rich Canarium album Extract on the Composition of the Gut Microbiota of Mice Fed a High-Fat Diet.
- Authors
Ning-Ning Zhang; Wen-Hui Guo; Han Hu; A-Rong Zhou; Qing-Pei Liu; Bao-Dong Zheng; Shao-Xiao Zeng
- Abstract
This study investigated the influence of Canarium album extract (CAext) on intestinal microbiota composition of mice fed a high-fat diet (HFD). Kun Ming (KM) mice were fed either a normal chow diet or a HFD for six weeks. At the seventh week, HFD-fed mice were gavaged daily with saline, or a different dose of CAext for four weeks, respectively. Then, the composition of the gut microbiota was analyzed by high-throughput sequencing technology. Analysis of fecal microbial populations, grouped by phyla, showed significant increases of Firmicutes and Verrucomicrobia, but a decrease of Bacteroidetes in all CAext-fed mice. Particularly, CAext gavage in a low dose or a medium dose caused a significant increase in the proportion of Akkermansia. These findings suggested that CAext can alter the gut microbiota composition of HFD-fed mice, and had a potential prebiotic effects on Akkermansia.
- Subjects
POLYPHENOLS; CANARIUM; BURSERACEAE; EXTRACTS; MICROBIOLOGY
- Publication
Molecules, 2018, Vol 23, Issue 9, p2188
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23092188