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- Title
Zerumbone Alleviates Neuropathic Pain through the Involvement of L-Arginine-Nitric Oxide-cGMP-K<sup>+</sup> ATP Channel Pathways in Chronic Constriction Injury in Mice Model.
- Authors
Zulazmi, Nurul Atiqah; Gopalsamy, Banulata; Min, Jasmine Chia Siew; Omar Farouk, Ahmad Akira; Sulaiman, Mohd Roslan; Bharatham, Hemabarathy; Perimal, Enoch Kumar
- Abstract
The present study investigates the involvement of the L-arginine-Nitric Oxide-cGMP-K+ ATP pathways responsible for the action of anti-allodynic and antihyperalgesic activities of zerumbone in chronic constriction injury (CCI) induced neuropathic pain in mice. The role of L-arginine-NO-cGMP-K+ was assessed by the von Frey and the Randall-Selitto tests. Both allodynia and hyperalgesia assessments were carried out on the 14th day post CCI, 30 min after treatments were given for each respective pathway. Anti-allodynic and antihyperalgesic effects of zerumbone (10 mg/kg, i.p) were significantly reversed by the pre-treatment of L-arginine (10 mg/kg), 1H [1,2,4]Oxadiazole[4,3a]quinoxalin-1-one (ODQ), a soluble guanosyl cyclase blocker (2 mg/kg i.p.) and glibenclamide (ATP-sensitive potassium channel blocker) (10 mg/kg i.p.) (p < 0.05). Taken together, these results indicate that systemic administration of zerumbone produces significant anti-allodynic and antihyperalgesic activities in neuropathic pain in mice possibly due to involvement of the L-arginine-NO-cGMP-PKG-K+ ATP channel pathways in CCI model.
- Subjects
NEUROPATHY; ARGININE; NITRIC oxide; CGMP-dependent protein kinase; ADENOSINE triphosphate; LABORATORY mice
- Publication
Molecules, 2017, Vol 22, Issue 4, p555
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22040555