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- Title
Molecular pathogenesis of Japanese encephalitis and possible therapeutic strategies.
- Authors
Kumar, Sanjay; Verma, Akanksha; Yadav, Pardeep; Dubey, Sumit Kumar; Azhar, Esam Ibraheem; Maitra, S. S.; Dwivedi, Vivek Dhar
- Abstract
Japanese encephalitis virus (JEV), a single-stranded, enveloped RNA virus, is a health concern across Asian countries, associated with severe neurological disorders, especially in children. Primarily, pigs, bats, and birds are the natural hosts for JEV, but humans are infected incidentally. JEV requires a few host proteins for its entry and replication inside the mammalian host cell. The endoplasmic reticulum (ER) plays a significant role in JEV genome replication and assembly. During this process, the ER undergoes stress due to its remodelling and accumulation of viral particles and unfolded proteins, leading to an unfolded protein response (UPR). Here, we review the overall strategy used by JEV to infect the host cell and various cytopathic effects caused by JEV infection. We also highlight the role of JEV structural proteins (SPs) and non-structural proteins (NSPs) at various stages of the JEV life cycle that are involved in up- and downregulation of different host proteins and are potentially relevant for developing efficient therapeutic drugs.
- Subjects
JAPANESE B encephalitis; UNFOLDED protein response; JAPANESE encephalitis viruses; CYTOSKELETAL proteins; ENDOPLASMIC reticulum
- Publication
Archives of Virology, 2022, Vol 167, Issue 9, p1739
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-022-05481-z