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- Title
Genetic analysis of two viroceptor genes of orf virus.
- Authors
Karki, Monu; Venkatesan, Gnanavel; Kumar, Amit; Pandey, A. B.
- Abstract
In the present study, we analyzed the chemokine-binding protein (CBP) and the GM-CSF/IL-2 inhibition factor (GIF) of orf virus (ORFV) isolates of sheep and goat origin from different geographical regions of India. Both are immunomodulatory proteins known for their unique strategy of establishing short-term immunity and re-infection in their host. The GIF gene is highly conserved, whereas the CBP gene is highly variable. Both the proteins have conserved potential N-glycosylation sites. The GIF protein contains the "WDPWV" motif responsible for receptor activation. In addition, the SUSHI/short consensus repeats (SCR) domain is reported for the first time in ORFV. Both proteins could potentially be used as immunotherapeutic agents in inflammatory diseases related to the overexpression of specific cytokines.
- Subjects
INDIA; GENES; REINFECTION; SUSHI; SHEEP; GENETIC overexpression; PESTE des petits ruminants; CLASSICAL swine fever
- Publication
Archives of Virology, 2022, Vol 167, Issue 7, p1577
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-022-05447-1