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- Title
Feline leukemia virus outbreak in the critically endangered Iberian lynx ( Lynx pardinus): high-throughput sequencing of envelope variable region A and experimental transmission.
- Authors
Geret, C.; Cattori, V.; Meli, M.; Riond, B.; Martínez, F.; López, G.; Vargas, A.; Simón, M.; López-Bao, J.; Hofmann-Lehmann, R.; Lutz, H.
- Abstract
The Iberian lynx is the most endangered felid species. During winter/spring 2006/7, a feline leukemia virus (FeLV) outbreak of unexpected virulence killed about 2/3 of the infected Iberian lynxes. All FeLV-positive animals were co-infected with feline hemoplasmas. To further characterize the Iberian lynx FeLV strain and evaluate its potential virulence, the FeLV envelope gene variable region A (VRA) mutant spectrum was analyzed using the Roche 454 sequencing technology, and an in vivo transmission study of lynx blood to specified-pathogen-free cats was performed. VRA mutations indicated weak apolipoprotein B mRNA editing enzyme and catalytic polypeptide-like cytidine deaminase (APOBEC) restriction of FeLV replication, and variants characteristic of aggressive FeLV strains, such as FeLV-C or FeLV-A/61C, were not detected. Cats exposed to FeLV/ Candidatus Mycoplasma haemominutum-positive lynx blood did not show a particularly severe outcome of infection. The results underscore the special susceptibility of Iberian lynxes to infectious diseases.
- Subjects
FELINE leukemia virus; LYNX pardinus; NUCLEOTIDE sequence; FELIDAE; ENDANGERED species; RETROVIRUS diseases; MICROBIAL virulence; MESSENGER RNA
- Publication
Archives of Virology, 2011, Vol 156, Issue 5, p839
- ISSN
0304-8608
- Publication type
Article
- DOI
10.1007/s00705-011-0925-z