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- Title
Dipeptide Piracetam Analogue Noopept Improves Viability of Hippocampal HT-22 Neurons in the Glutamate Toxicity Model.
- Authors
Antipova, T.; Nikolaev, S.; Ostrovskaya, P.; Gudasheva, T.; Seredenin, S.
- Abstract
Effect of noopept (N-phenylacetyl-prolylglycine ethyl ester) on viability of neurons exposed to neurotoxic action of glutamic acid (5 mM) was studied in vitro in immortalized mouse hippocampal HT-22 neurons. Noopept added to the medium before or after glutamic acid improved neuronal survival in a concentration range of 10-11-10-5 M. Comparison of the effective noopept concentrations determined in previous studies on cultured cortical and cerebellar neurons showed that hippocampal neurons are more sensitive to the protective effect of noopept.
- Subjects
DIPEPTIDES; HIPPOCAMPUS (Brain); NEURONS; GLUTAMIC acid; LABORATORY mice
- Publication
Bulletin of Experimental Biology & Medicine, 2016, Vol 161, Issue 1, p58
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-016-3344-z