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- Title
Effect of Gadolinium Chloride on the Growth and Metastasizing of Lewis Pulmonary Adenocarcinoma in Mice.
- Authors
S. Zhanaeva; T. Alekseenko; T. Korolenko
- Abstract
A single intraperitoneal injection of GdCl3 in doses of 14 or 28 mg/kg to mice with intravenously transplanted Lewis pulmonary adenocarcinoma on days 3 or 8 after tumor transplantation reduced the mean number of tumor metastases in the lungs. The effect of GdCl3 was more pronounced if it was injected at the stage of tumor dissemination (day 8). The positive antimetastatic effect of GdCl3 was presumably due to its capacity to macrophage depression. The direct (not mediated through mononuclear phagocyte system cells) effect of GdCl3 on tumor cells cannot also be excluded.
- Subjects
LUNG cancer; ADENOCARCINOMA; GADOLINIUM; INTRAPERITONEAL injections; METASTASIS; LABORATORY mice; CANCER invasiveness
- Publication
Bulletin of Experimental Biology & Medicine, 2008, Vol 146, Issue 5, p612
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-009-0346-0