We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The synthesis of 2,6-diamino-9-ß-D-arabinofuranosylpurine from vidarabine by the selective nitration and ammonolysis.
- Authors
Xia, Ran; Sun, Li-Ping; Yang, Xi-Ning; Qu, Gui-Rong
- Abstract
A practical synthesis of 2,6-diamino-9-ß-D-arabinofuranosylpurine from the commercially available vidarabine is reported. Treatment of fully protected vidarabine with 2,2,2-trifluoroacetic anhydride and tetrabutylammonium nitrate introduced a -NO2 group in the C2 position in high yield. 2,6-Diamino-9-ß-D-arabinofuranosylpurine was synthesised in three steps and 61% total yield after ammonolysis of the -NO2 accompanied by removal of the benzoyl groups.
- Subjects
CHEMICAL synthesis; AMMONOLYSIS; TRIFLUOROACETIC acid; ANHYDRIDES; BENZOYL compounds
- Publication
Journal of Chemical Research, 2015, Vol 39, Issue 11, p665
- ISSN
1747-5198
- Publication type
Article
- DOI
10.3184/174751915X14451842184314