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- Title
How Similar Are Inbred Rats? The Influence of Anatomical Variations, Shipment and Sampling Time on Experimental Surgery.
- Authors
Jin, H.; Huang, H.; Zhang, J.; Dirsch, O.; Dahmen, U.
- Abstract
Variations among inbred rats in terms of anatomy and routine laboratory values can potentially blur surgical experimental results. Therefore, a retrospective analysis aiming at investigating hepatic and perihepatic anatomical variations, liver weight, body weight, liver weight/body weight ratio (LBWR), variations in routine laboratory values, and the influence of shipment and repeated sampling was performed. In our study, liver weight of rats seemed to be strain-specific. LBWR was weakly and negatively correlated with body weight in rats. A statistically significant difference in routine blood tests was found among normal rats grouped by different body weight or shipment. Weekly repeated sampling from the same rats revealed a statistically significant difference in a blood test. In conclusion, the fact that variation among rats or their environment can blur the results of a surgical experimental study should be kept in mind. Copyright © 2012 S. Karger AG, Basel
- Subjects
EXPERIMENTAL surgery; ANIMAL breeding research; RAT anatomy; CLINICAL chemistry; HEMATOLOGY
- Publication
European Surgical Research, 2012, Vol 49, Issue 2, p53
- ISSN
0014-312X
- Publication type
Article
- DOI
10.1159/000333395