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- Title
Cancer genome-sequencing study design.
- Authors
Mwenifumbo, Jill C.; Marra, Marco A.
- Abstract
Discoveries from cancer genome sequencing have the potential to translate into advances in cancer prevention, diagnostics, prognostics, treatment and basic biology. Given the diversity of downstream applications, cancer genome-sequencing studies need to be designed to best fulfil specific aims. Knowledge of second-generation cancer genome-sequencing study design also facilitates assessment of the validity and importance of the rapidly growing number of published studies. In this Review, we focus on the practical application of second-generation sequencing technology (also known as next-generation sequencing) to cancer genomics and discuss how aspects of study design and methodological considerations - such as the size and composition of the discovery cohort - can be tailored to serve specific research aims.
- Subjects
CANCER genetics; CANCER prevention; GENOMICS; GENE enhancers; EPIDERMAL growth factor
- Publication
Nature Reviews Genetics, 2013, Vol 14, Issue 5, p321
- ISSN
1471-0056
- Publication type
Article
- DOI
10.1038/nrg3445