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- Title
No evidence for association between 1858 C/T single-nucleotide polymorphism of PTPN22 gene and primary Sjögren's syndrome.
- Authors
Ittah, M.; Gottenberg, J.-E.; Proust, A.; Hachulla, E.; Puechal, X.; Loiseau, P.; Mariette, X.; Miceli-Richard, C.
- Abstract
One-third of first-degree relatives of patients with primary Sjögren's syndrome (pSS) suffer from other autoimmune diseases, including type I diabetes, systemic lupus erythematosus and autoimmune thyroiditis. Recently, 1858 C/T polymorphism of PTPN22 gene was reported to predispose to these autoimmune diseases. We decided to investigate whether PTPN22 gene polymorphism was also involved in the genetic predisposition to pSS in a case–control study, including 183 patients with pSS and 172 healthy controls. No significant differences in allele (T allele frequency: 7.7% in patients with pSS vs 7.8% in controls, P=0.9) and genotype frequencies of PTPN22 polymorphism were detected between patients with pSS and controls. PTPN 22 gene polymorphism was not associated with a specific pattern of autoantibody secretion either. Thus, 1858 C/T polymorphism of PTPN22 gene is not involved in genetic predisposition to pSS.Genes and Immunity (2005) 6, 457–458. doi:10.1038/sj.gene.6364229; published online 3 June 2005
- Subjects
SJOGREN'S syndrome; KERATOCONJUNCTIVITIS sicca; RHEUMATOID arthritis; AUTOIMMUNE thyroiditis; SYSTEMIC lupus erythematosus; GENETIC polymorphisms
- Publication
Genes & Immunity, 2005, Vol 6, Issue 5, p457
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364229