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- Title
Paraneoplastic opsoclonus-myoclonus syndrome as a rare presentation of parotid adenocarcinoma.
- Authors
Yılmaz, Buket Özkara
- Abstract
Paraneoplastic Opsoclonus-Myoclonus Ataxia Syndrome (POMA) is a rare neurological condition that affects approximately 1 in 10,000,000 people annually. This syndrome is poorly understood and can lead to long-term cognitive, behavioral, and motor complications. Opsoclonus is characterized by involuntary, rapid, repetitive, multi-vectorial oscillations of the eyes occurring in all directions of gaze. It is accompanied by diffuse or focal body myoclonus and may or may not include ataxia and other cerebellar signs. POMA is typically a paraneoplastic syndrome associated with neuroblastoma in childhood and breast carcinoma or small-cell lung carcinoma in adults. Additionally, viral or toxic agents are known to play a role in its etiology, and the immune system is involved in the pathogenesis. We report a case of a 41-year-old man with anti-Ri antibody opsoclonus-myoclonus syndrome and parotid adenocarcinoma involvement. After diagnosing opsoclonus-myoclonus syndrome, the patient underwent multimodal immunotherapy treatment, resulting in partial remission of the neurological symptoms.
- Subjects
ADENOCARCINOMA; EYE; ATAXIA; PARANEOPLASTIC syndromes; RARE diseases; BREAST tumors; IMMUNOTHERAPY; MOVEMENT disorders; TREATMENT effectiveness; OPSOCLONUS-Myoclonus syndrome; PAROTID gland tumors; COGNITION disorders; LUNG cancer; IMMUNOSUPPRESSION
- Publication
Journal of Surgery & Medicine (JOSAM), 2024, Vol 8, Issue 5, p93
- ISSN
2602-2079
- Publication type
Article
- DOI
10.28982/josam.7701