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- Title
Antibody targeted drugs as cancer therapeutics.
- Authors
Schrama, David; Reisfeld, Ralph A.; Becker, Jürgen C.
- Abstract
Treatment of cancer is a double-edged sword: it should be as aggressive as possible to completely destroy the tumour, but it is precisely this aggressiveness which often causes severe side effects — a reason why some promising therapeutics can not be applied systemically. In addition, therapeutics such as cytokines that physiologically function in a para- or autocrine fashion require a locally enhanced level to exert their effect appropriately. An elegant way to accumulate therapeutic agents at the tumour site is their conjugation/fusion to tumour-specific antibodies. Here, we discuss recent preclinical and clinical data for antibody–drug conjugates and fusion proteins with a special focus on drug components that exert their antitumour effects through normal biological processes.
- Subjects
CANCER treatment; MONOCLONAL antibodies; IMMUNOGLOBULINS; CYTOKINES; CELLULAR immunity; PROTEINS
- Publication
Nature Reviews Drug Discovery, 2006, Vol 5, Issue 2, p147
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd1957