The article discusses the study "Nuclear-Receptor-Mediated Telomere Insertion Leads to Genome Instability in ALT cancers," by researcher P. Marzec and colleagues and published in the journal journal "Cell." Topics discussed include impact of dysfunctional telomeres in inducing genomic instability, alternative lengthening of telomeres (ALT) for telomere maintenance in cancer cells and occurrence of ALT in sarcoma.