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- Title
Effects of a high‐fat diet on rat epididymis.
- Authors
Falvo, Sara; Latino, Debora; Santillo, Alessandra; Chieffi Baccari, Gabriella; Senese, Rosalba; Nuzzolillo, Francesca; Di Fiore, Maria Maddalena
- Abstract
The epididymis plays an essential role in reproduction, promoting sperm cell maturation. In this study, we investigated the effects of a high‐fat diet (HFD) in the three regions of the epididymis of rats, including caput, corpus, and cauda. Our results showed an increase in malondialdehyde and a decrease in superoxide dismutase, which indicated an increase in oxidative stress in all segments of the epididymis. The cellular response mechanisms were mostly detected in the corpus/cauda regions, which showed an increase in apoptosis, probably for eliminating dysfunctional cells arising from HFD‐induced oxidative stress, and a decrease in mitophagy. Additionally, an increase in lipophagy to prevent lipid accumulation and a decrease in cell proliferation were recorded in the corpus. Research Highlights: High‐fat diet induced oxidative stress in all segments of the epididymis.In the corpus and cauda, apoptosis occurred to eliminate dysfunctional cells.In the corpus, lipophagy occurred to cope with lipid accumulation.
- Subjects
HIGH-fat diet; EPIDIDYMIS; OXIDATIVE stress; SUPEROXIDE dismutase; RATS
- Publication
Journal of Experimental Zoology: Part A Ecological & Integrative Physiology, 2023, Vol 339, Issue 6, p535
- ISSN
2471-5638
- Publication type
Article
- DOI
10.1002/jez.2698