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- Title
GROWTH AND DEVELOPMENT SYMPOSIUM: STEM AND PROGENITOR CELLS IN ANIMAL GROWTH: The regulation of beef quality by resident progenitor cells 1.
- Authors
Fu, Xing; Li, Chaoyang; Liu, Qianglin; McMillin, Kenneth W
- Abstract
The intramuscular adipose tissue deposition in the skeletal muscle of beef cattle is a highly desired trait essential for high-quality beef. In contrast, the excessive accumulation of crosslinked collagen in intramuscular connective tissue contributes to beef toughness. Recent studies revealed that adipose tissue and connective tissue share an embryonic origin in mice and may be derived from a common immediate bipotent precursor in mice and humans. Having the same linkages in the development of adipose tissue and connective tissue in beef, the lineage commitment and differentiation of progenitor cells giving rise to these tissues may directly affect beef quality. It has been shown that these processes are regulated by some key transcription regulators and are subjective to epigenetic modifications such as DNA methylation, histone modifications, and microRNAs. Continued exploration of relevant regulatory pathways is very important for the identification of mechanisms influencing meat quality and the development of proper management strategies for beef quality improvement.
- Subjects
ANIMAL development; PROGENITOR cells; BEEF quality; CONNECTIVE tissues; ADIPOSE tissues
- Publication
Journal of Animal Science, 2019, Vol 97, Issue 6, p2658
- ISSN
0021-8812
- Publication type
Article
- DOI
10.1093/jas/skz111