We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mucosal Healing in Crohn's Disease: Bull's Eye or Bust? "The Pro Position".
- Authors
O'Moráin, Neil; Doherty, Jayne; Stack, Roisin; Doherty, Glen A.
- Abstract
Background: Crohn's disease (CD) is a chronic inflammatory disorder affecting the gastrointestinal tract with disease behaviour based on the depth and severity of mucosal injury. Cumulative injury can result in complications including stricture formation and penetrating complications which often require surgical resection of diseased segments of the intestine resulting in significant morbidity. Accurate assessment of disease activity and appropriate treatment is essential in preventing complications. Summary: Treatment targets in the management of CD have evolved with the advent of more potent immunosuppressive therapy. Targeting the resolution of sub-clinical inflammation and achieving mucosal healing is associated with the prevention of stricturing and penetrating complications. Identifying non-invasive modalities to assess mucosal healing remains a challenge. Key Messages: Mucosal healing minimizes the risk of developing disease complications, prolongs steroid-free survival, and reduces hospitalization and the need for surgical intervention.
- Subjects
CROHN'S disease; GASTROINTESTINAL diseases; GASTROINTESTINAL tumors treatment; FISTULA; THERAPEUTICS
- Publication
Inflammatory Intestinal Diseases, 2022, Vol 7, Issue 1, p36
- ISSN
2296-9403
- Publication type
Article
- DOI
10.1159/000519521