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- Title
Combination of 5% cysteamine and 4% nicotinamide in melasma: Efficacy, tolerability, and safety.
- Authors
Crocco, Elisete Isabel; Torloni, Liliana; Fernandes, Paula Bonilha; de Campos, Maria Elisa Barbosa Bueno; Gonzaga, Maura; Silva, Fernanda Cristina; Nasario, João Paulo Sardin; Guerra, Lucas Offenbecker; Csipak, Angélica Richart; Castilho, Vivienne Carduz
- Abstract
Background: Melasma is a chronic dermatosis that impacts the patient's quality of life and can present considerable challenges in terms of effective treatment. Objective: To evaluate the effectiveness, tolerability, and safety of 5% cysteamine combined with 4% nicotinamide in female subjects with melasma. Methods: This single‐center, single‐arm, prospective, open‐label study evaluated patients with melasma using a combination cream of 5% cysteamine and 4% nicotinamide in a progressive regimen (60 min in the first month, 120 min in the second month, and 180 min in the third month). Results: Overall, 35 treated subjects exhibited reduced modified Melasma Area and Severity Index (mMASI) (p < 0.001) and decreased MelasQoL scores (p < 0.001), accompanied by improved brightness, luminosity, homogeneity, and spot intensity (p < 0.001). Photographic and colorimetric analysis revealed smaller spots and improved homogeneity. Limitations: Adherence to progressive daily treatment could not be evaluated long‐term. Conclusion: A combination cream comprising 5% cysteamine and 4% nicotinamide was effective, tolerable, and safe for treating melasma.
- Subjects
MELANOSIS; NICOTINAMIDE; CYSTEAMINE; COLORIMETRIC analysis; QUALITY of life
- Publication
Journal of Cosmetic Dermatology, 2024, Vol 23, Issue 5, p1703
- ISSN
1473-2130
- Publication type
Article
- DOI
10.1111/jocd.16183