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- Title
Monoclonal Antibodies to Immunogenic Lymphoma Cell Variants Displaying Impaired Neoplastic Properties: Characterization and Applications.
- Authors
Hochman, Jacob; Park, Sang S.; Lazarovici, Philip; Bergel, Michael; Gottesman, Michael M.
- Abstract
Immunogenic, nontumorigenic cell variants derived from the highly tumorigenic mouse lymphoma cell line S-49 were used to raise monoclonal antibodies (MAbs) in syngeneic BALB/c mice. MAbs of the following specifications were derived: () MAbs that interacted perferentially with the immunogenic variants, () MAbs that interacted with both immunogenic variants and parental tumorigenic cells, and () a MAb that interacted with both immunogenic and tumorigenic S-49 cells and the normal BALB/c splenocytes. Six MAbs raised in this way were found to recognize at least five different cell-surface epitopes. Functional analysis of the different MAbs suggested their potential usefulness in passive immunization against parental tumorigenic cells as well as in enrichment of immunogenic cells from a mixed population containing a preponderance of tumorigenic cells. [J Natl Cancer Inst 82:1821–1826, 1990]
- Publication
JNCI: Journal of the National Cancer Institute, 1990, Vol 82, Issue 23, p1821
- ISSN
0027-8874
- Publication type
Article